RARECHEM AL BF 1190
Methyl 6-fluorosalicylate
CAS: 72373-81-0
Molecular Formula: C8H7FO3
RARECHEM AL BF 1190 - Names and Identifiers
RARECHEM AL BF 1190 - Physico-chemical Properties
| Molecular Formula | C8H7FO3 |
| Molar Mass | 170.14 |
| Melting Point | 71°C |
| Boling Point | 65-70°C 1,7mm |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Irritant |
| MDL | MFCD00153207 |
RARECHEM AL BF 1190 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Class | IRRITANT |
RARECHEM AL BF 1190 - Reference Information
| introduction | methyl 2-fluoro-6-hydroxybenzoate is a pharmaceutical intermediate, which can be made of gallic acid as raw material, treated with methanol esterification and dimethyl sulfate etherification to methyl benzoate substituted by trimethyl ether, and then interact with the complex reagent ZnCl2/CH3CH2COOH to selectively remove methyl ether, methyl 2-fluoro-6-hydroxybenzoate was obtained in higher yield. |
| preparation | under nitrogen protection, gallic acid (10g,0.059mL) is dissolved in 50mL of methanol, concentrated sulfuric acid in catalytic amount is dropped under stirring, reflux for 8 h, sodium hydroxide solution (80 mL,33%) and dimethyl sulfate (60g) are alternately dropped into the reactor. After dropping, sodium hydroxide solution is used to adjust to strong alkalinity. The temperature is raised to 80 ℃ to continue the reaction for 8 hours. After the reaction is completed, chloroform is used for extraction (40 mL × 3), anhydrous sodium sulfate is dried, thin layer detection is a single point, solvent is evaporated, insoluble impurities are filtered out in a short column to obtain white solid methyl 2-fluoro-6-hydroxybenzoate with a yield of 95%. |
Last Update：2024-04-09 20:52:54
